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What’s going on right now!
THURSDAY — November 25th, 2021
Čtvrtek — 25. listopadu 2021
MADRID ROOM
OLOMOUC ROOM
FRIDAY — November 26th, 2021
Pátek — 26. listopadu 2021
EVROPA ROOM
SATURDAY — November 27th, 2021
Sobota — 27. listopadu 2021
MADRID ROOM
PROGRAM
THURSDAY / ČTVRTEK 25th November 2021 / MADRID ROOM / 13:00 - 15:00
Novel drugs and therapies / 13:00 — 15:00
Chairs: Petr Džubák, Milan Urban
13:00 – 13:15 Welcome speech
Marián Hajdúch
13:15 – 13:30 Biological evaluation of 225Ac-PSMA derivatives for alpha therapy in prostate cancer
Zbyněk Nový
13:30 – 13:45 Anti-SARS-CoV-2 activity of one existing anti-inflammatory drug
Ermin Schadich
13:45 – 14:00 Determination of biological activity of compounds from IMTM Proprietary Library based on their cytotoxicity profiling in HTS facility
Soňa Gurská
14:00 – 14:15 Highly active anticancer drug, PNH173, mechanism of action
Petr Džubák
14:15 – 14:30 Synthesis of fluorinated derivatives 2-phenyl-3-hydroxy-4(1H)-quinolinone and study of their anticancer activity
Jiří Řehulka
14:30 – 14:45 Bioisosteric approach in the improvement of selectivity in cytotoxic analogues of betulinic acid
Milan Urban
14:45 – 15:00 68Ga-Ornibactin for positron emission tomography imaging of bacteria from Burkholderia cepacia complex Kateřina Bendová
15:00 — 15:30 COFFEE BREAK
THURSDAY / ČTVRTEK 25th November 2021 / OLOMOUC ROOM / 13:00 - 15:00
Interdisciplinary research in pathology / 13:00 — 15:00
Chairs: Jiří Ehrmann, Jan Bouchal
13:00 – 13:15 Welcome speech
Jiří Ehrmann
13:15 – 13:30 Multiple myeloma 2000+
Jiří Minařík
13:30 – 13:45 Current approach to typing systemic and localised amyloidosis
Patrik Flodr
13:45 – 14:00 A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment
Katarína Chromá
14:00 – 14:15 Cannabidiol-induced expression of metallothioneins attenuate the anticancer effect of disulfiram
Tereza Buchtová
14:15 – 14:30 Iodine Contrast Medium Affects Urine Cytology Assessement – A Prospective Single Blinded Study And Its Impact For Urological Practice
Milan Král
14:30 – 14:45 Cell surface antigen signature and its plasticity in breast and prostate cancer
Karel Souček
14:45 – 15:00 Inhibition of aryl hydrocarbon receptor (AhR) expression in colon cancer cells disrupts cell proliferation, energy metabolism and expression of enzymes involved in fatty acid synthesis
Jan Vondráček
15:00 — 15:30 COFFEE BREAK
FRIDAY / PÁTEK 26th November 2021 / EVROPA ROOM / 8:15 - 10:00
The session of the Czech Society of Pathologists / 08:15 — 10:00
Chairs: Pavel Dundr, Zdeněk Kolář, Jiří Ehrmann
8:15 – 8:25 Welcome speech
Zdeněk Kolář, Pavel Dundr, Jiří Ehrmann, Marián Hajdúch, Jana Vaculová
8:25 – 8:45 Hlava’s institute of pathology, professor Jaroslav Hlava and his successors
Pavel Dundr
8:45 – 9:00 Comparison of 5 different scoring methods in the evaluation of inflammatory infiltration (tumor infiltrating lymphocytes – TILs) in superficial spreading and nodular melanoma (Hlava‘s award 2019)
Kristýna Němejcová
9:00 – 9:15 Extracellular Amyloid Deposits in Alzheimer’s and Creutzfeldt–Jakob Disease: Similar Behavior of Different Proteins? (Lambl‘s award 2020)
Nikol Jankovská
9:15 – 9:30 Central Pathology Review in SENTIX, A Prospective Observational International Study on Sentinel Lymph Node Biopsy in Patients with Early-Stage Cervical Cancer (ENGOT-CX2) (Hlava‘s award 2020)
Kristýna Němejcová
9:30 – 10:00 INVITED LECTURE: Androgen receptor coregulatory proteins and endocrine and chemotherapies for prostate cancer
Zoran Culig, Innsbruck Medical University
10:00 — 10:30 COFFEE BREAK
FRIDAY / PÁTEK 26th November 2021 / EVROPA ROOM / 13:30 - 15:50
COVID-19: Nemoc plná překvapení / 13:30 — 15:50
Chairs: Roman Prymula, Marián Hajdúchnn
13:30 – 13:50 Diagnostika infekce virem SARS-CoV-2
Pavel Dřevínek
13:50 – 14:10 Patologie onemocnění COVID-19
Radoslav Matěj
14:10 – 14:30 COVID-19 — když data a informace nejsou totéž
Ladislav Dušek
14:30 – 14:50 Účinnost a reaktogenita vakcín proti COVID-19, máme jinou alternativu jak zastavit pandemii?
Roman Prymula
14:50 – 15:10 Farmakologická prevence a léčba pacientu
Petr Smejkal
15:10 – 15:30 Pandemie: čím jsme si prošli a kam směřujeme
Marián Hajdúch
15:30 – 15:50 Moderovaná diskuze
15:50 – 17:00 POSTER SECTION — Poster presenters are required to be ready for discussions
19:00 SOCIAL EVENT
SATURDAY / SOBOTA 27th November 2021 / MADRID ROOM / 9:00 - 11:30
Multiplex imunohistochemistry and data management / 09:00 — 11:30
Chairs: Jiří Ehrmann, Jan Bouchal
9:00 – 9:30 INVITED LECTURE: Spatial Phenotyping of Immune Cell Subsets in Patients with Lethal COVID-19
Paul Murray, University of Birmingham, University of Limerick
9:30 – 9:45 Awakening of digital pathology in Covid 19 pandemic – time to come to real life
Jiří Ehrmann
9:45 – 10:10 Contribution of Digital Pathology in Multidisciplinary Tumor Board Approach Precising Medicine
Patrik Flodr
10:10 – 10:25 Artificial Intelligence and Multiplex Bioimaging in Translational Cancer Research
Mariam Gachechiladze
10:25 – 10:45 Ultra high content imaging using MICS technology on the MACSima™ Imaging Platform
Bernd Müller-Zülow
10:45 – 11:00 Introduction to infrastructures for medical data
Petr Holub
11:00 – 11:15 ELIXIR Czech Republic – Large Infrastructure for biological data pursuits steps towards personalized medicine
Jiří Vondrášek
11:15 – 11:30 Software tools for data stewardship in personalized and translational medicine
Marián Hajdúch
11:30 — 11:45 COFFEE BREAK
SATURDAY / SOBOTA 27th November 2021 / MADRID ROOM / 14:00 - 15:15
Molecular pathology / 14:00 — 15:15
Chairs: Jana Steigerová, Josef Srovnal
9:14:00 – 14:15 Circulating Tumor Cells Detection in Solid Tumors using the CytoTrack instrument
Pavel Stejskal
14:15 – 14:30 Key genes and pathways associated with Skp2 and Slug in prostate cancer by bioinformatics analysis
Gvantsa Kharaishvili
14:30 – 14:45 The cell painting assay
Alžběta Srovnalová
14:45 – 15:00 Transcriptomic Profiling Identified Lnc-GOLGA6A-1 as a Negative Prognostic Biomarker for Meningioma Recurrence
Hanuš Slavík
15:00 – 15:15 Ceremonial closing and awards for the best oral and poster presentation
Sponsored by foundation Cancer Research Czech Republic
THURSDAY / ČTVRTEK 25th November 2021 / MADRID ROOM / 15:30 - 18:00
Biomarkers in personalized medicine / 15:30 — 18:00
Chairs: Juan Bautista De Sanctis, Lukáš Najdekr
15:30 – 15:45 Metabolite and lipid profiling of lung and breast cancer
Aleš Kvasnička
15:45 – 16:00 Colon Cancer and Perturbations of the Sphingolipid and Glycosphingolipid Metabolism
Miroslav Machala
16:00 – 16:15 Comprehensive LC-MS approach for diagnosis of monogenic disorders
Barbora Piskláková
16:15 – 16:30 Proteomic analysis of exhaled breath condensate could be used for non-invasive lung cancer diagnostics and distinguish it from COPD
Jana Václavková
16:30 – 16:45 Could be the biomarkers of gynecological diseases detected from cervical mucus?
Tomáš Oždián
16:45 – 17:00 Novel UHPLC-MS method for detailed analysis of lipid species using a scheduled MS/MS acquisition approach for improved metabolite annotation
Lukáš Najdekr
17:00 – 17:15 Targeted metabolomic and lipidomic study of SHR24 rat models with tauopathy
Dana Dobešová
17:15 – 17:30 Therapeutic targeting of repurposed anticancer drugs for protein aggregation: Example of tau aggregates Narendran Annadurai
17:30 – 17:45 Supplementation with polyunsaturated and saturated fatty acids enhance NK cyto toxic response in Sprague Dawley-Rats. Effect of gender and age
Juan Bautista De Sanctis
17:45 – 18:00 Age prediction through detection of DNA methylation
Lucie Kotková
THURSDAY / ČTVRTEK 25th November 2021 / OLOMOUC ROOM / 15:30 - 17:40
Clinical and molecular pathology / 15:30 — 17:40
Chairs: Gabriela Dostálová, Zdeněk Kolář
15:30 – 15:45 Role imunohistochemie v diagnostice atypické endometriózy Jiří Lenz
15:45 – 16:00 Teamwork in Thyroid Diseases Diagnostics and Treatment. Total Thyroidectomy Can Still Remain the Method of Choice in Some Bethesda III FNAB Cases
Jaroslava Dušková
16:00 – 16:15 Patofyziologie a patologie M. Gaucher a M. Fabry
Helena Hůlková
16:15 – 16:30 Soubor biopsií ledvin u M. Fabry. Provedené nefrologické screeningy v ČR
Eva Honsová
16:30 – 16:40 Další histopatologická vyšetření u M. Gaucher a M. Fabry
Helena Hůlková
16:40 – 16:55 Bank of Clinical Specimens: Bridging the gap in translational research Roman Hrstka
16:55 – 17:10 Cytokeratin 7 expression as a predictor of an unfavorable prognosis in colorectal carcinoma
Jan Hrudka
17:10 – 17:25 Morphological study of HNSCC focused on perinerual invasion – a single institutional study with five year follow up
Pavel Hurník
17:25 – 17:40 Identification of candidate genes underlying soft tissue sarcoma progression
Jiří Hatina
FRIDAY / PÁTEK 26th November 2021 / EVROPA ROOM / 10:30 - 12:30
Comprehensive genomic tumor profiling powered by GENETICA & ILLUMINA 10:30 — 12:30
Chairs: Pavel Dundr, Jiří Drábek, Jeroen Adema, Ondřej Slabý
10:30 – 11:00 Comprehensive genomic tumor profiling
Jeroen Adema
11:00 – 11:30 Higher degree of personalization of cancer treatment (precision oncology) using comprehensive genomic profiling: experience from two molecular tumor boards
Ondřej Slabý
11:30 – 11:45 The informatic road to clinical report from NGS somatic testing
Ondřej Brzoň
11:45 – 12:00 Clonal somatic variants in hematopoietic cells in relation to age and stroke
Rastislav Slavkovský
12:00 – 12:30 The Value of Comprehensive Genomic Profiling of Metastatic Cancer Using NGS
Brigitte Maess
12:30 — 13:30 LUNCH
FRIDAY / PÁTEK 26th November 2021 / OLOMOUC ROOM / 15:30 - 17:15
XXIV. Congress of the Czech Society of Histotechnologists 15:30 — 17:15
Chairs: Jana Vaculová, Daniela Indrová
15:30 – 15:45 Využití a výhody histotopogramu v histologické diagnostice
Kateřina Gospošová
15:45 – 16:00 Využití histologického zpracování modelů k detekci závažnosti postižení tlustého střeva ulcerozní kolitidou
Jozef Škarda
16:00 – 16:15 Duální nepřímá imunofluorescence na histologických řezech
Alena Poláková
16:15 – 16:30 Multiplexní imunofluorescence v histologii
Tereza Hulínová
16:30 – 16:45 Zpracování tělních tekutin formou cytobloku
Lucie Hocková
16:45 – 17:00 Informace k přípravě kompetenčních modelů
Miroslava Lamplotová
17:00 – 17:15 Informace z výboru ČSHL
Jana Vaculová, Pavla Krystková
SATURDAY / SOBOTA 27th November 2021 / MADRID ROOM / 11:45 - 13:00
Prognostic, predictive and immune response biomarkers / 11:45 — 13:00
Chairs: Markéta Kolečková, Jozef Škarda
11:45 – 12:00 Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature
Jan Hrudka
12:00 – 12:15 Antitumor immune response – significance and recommended procedures for assessing the intensity of tumor-infiltrating lymphocytes / plasma cells (TILs) in solid tumors
Markéta Kolečková
12:15 – 12:30 Prognostic value of tumor-infiltrating lymphocytes (TILs) and their association with PD-L1 expression and DNA repair protein RAD51 in patients with resected non-small cell lung carcinoma Jozef Škarda
12:30 – 12:45 Predictive relevance of microRNA in patienta with NSCLC undergoing palliative chemotherapy Kateřina Houfková
12:45 – 13:00 LC3A positive “stone like structures” are differentially associated with survival outcomes and CD68 macrophage infiltration in patients with lung adenocarcinoma and squamous cell carcinoma
Jozef Škarda
13:00 — 14:00 LUNCH